Portelius E, Durieu E, Bodin M, Cam M, Pannee J, Leuxe C, Mabondzo A, Oumata N, Galons H, Lee JY, Chang YT, Stϋber K, Koch P, Fontaine G, Potier MC, Manousopoulou A, Garbis SD, Covaci A, Van Dam D, De Deyn P, Karg F, Flajolet M, Omori C, Hata S, Suzuki T, Blennow K, Zetterberg H, Meijer L.

J Alzheimers Dis. 2016 Oct 18;54(4):1593-1605. (IF: 3.920)


Ben Halima S, Mishra S, Raja KM, Willem M, Baici A, Simons K, Brüstle O, Koch P, Haass C, Caflisch A, Rajendran L.

Specific Inhibition of beta-Secretase Processing of the Alzheimer Disease Amyloid Precursor Protein

Cell Rep. 2016 Mar 8;14(9):2127-41. doi: 10.1016/j.celrep.2016.01.076. Epub 2016 Feb 25. (IF: 7.870)


Kumar, S., Wirths, O., Stüber, K., Wunderlich, P., Koch, P., Theil, S., Rezaei-Ghaleh, N., Zweckstetter, M., Bayer, TA., Brüstle, O., Thal, DR., Walter, J.

Phosphorylation of the amyloid beta-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.

Acta Neuropathologica, 2016 Feb 22 (ahead of print) (IF: 9.320)


Koch, P.

'Direct Conversion Provides Old Neurons from Aged Donors' Skin'

Cell Stem Cell, (2015)



Doerr J, Böckenhoff A, Ewald B, Ladewig J, Eckhardt M, Gieselmann V, Matzner U, Brüstle O, Koch P.

Arylsulfatase A overexpressing human iPSC-derived neural cells reduce CNS sulfatide storage in a mouse model of metachromatic leukodystrophy

Mol Ther. 2015 Jun 10. doi: 10.1038/mt.2015.106. (IF: 6.825)


K C Vadodaria, J Mertens, A Paquola, C Bardy, X Li, R Jappelli, L Fung, M C Marchetto, M Hamm, M Gorris, P Koch and F H Gage

Generation of Functional Human Serotoergic Neurons from Fibroblasts

Mol Psychiatry advance online publication, October 27, 2015; doi:10.1038/mp.2015.161 (IF: 13.314)


Ladewig, J., Koch, P., Brüstle, O. (2015)
In vitro migration assays for neural stem cells, intermediate neurogenic progenitors and immature neurons
Bio-Protocol 5(1):e1371



Ladewig, J.*, Koch, P.*, Brüstle, O.

Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration

Nature Neuroscience 17(1):24-6. doi: 10.1038/nn.3583. Epub 2013 Nov 17. (2014), (* equal contribution) (IF: 16.724)

Selected by Faculty of 1000

Nat Neurosci 2013 Ladewig.pdf (920612)


Avaliani, N., S Rensen, AT., Ledri, M., Bengzon, J., Koch, P., Brüstle, O., Deisseroth, K., Andersson, M., Kokaia, M.

Optogenetics reveal delayed afferent synaptogenesis on grafted human induced pluripotent stem cell-derived neural progenitors

Stem Cells  doi: 10.1002/stem.1823. (2014) (IF: 7.871)


Tatarishvili, J., Oki, K., Monni, E., Koch, P., Memanishvili, T., Buga, A.-M., Verma, V., Popa-Wagner, A., Brüstle., O., Lindvall, O., Kokaia, Z.

Human induced pluripotent stem cells improve recovery in stroke-injured aged rats

Restorative Neurology and Neuroscience 32(4):547-58. doi: 10.3233/RNN-140404. (2014) (IF: 2,9)



Mertens, J., Stüber, K., Wunderlich, P., Ladewig, J., Vandenberghe, R., Vandenbulcke, M., van Damme, P., Walter, J., Brüstle, O., and Koch, P.

APP Processing in Human Pluripotent Stem Cell-Derived Neurons is Resistant to NSAID-based γ-Secretase Modulation

Stem Cell Reports 1(6):491-8. doi: 10.1016/j.stemcr.2013.10.011. (2013) (IF: no IF yet)

Stem Cell Reports 2013 Mertens.pdf (957875)


Mertens, J., Stüber, K., Poppe, D., Doerr, J., Ladewig, J., Brüstle, O., Koch, P.
Embryonic stem cell-based modeling of tau pathology in human neurons
Am J Pathol 182(5):1769-1779 (2013) (IF: 5.224)

The American journal of pathology 2013 Mertens.pdf (2126729)


Tornero, D., Wattanant, S., Madsen, MG., Koch, P., Wood, J., Tatarishvili, J., Mine, Y., Ge, R., Monni, E., Devaraju, K., Hevner, RF., Brüstle, O., Lindvall, O., Kokaia, Z.

Human iPS cell-derived cortical neurons integrate in stroke-injured cortex and impove functional recovery

Brain 136(Pt 12):3561-77. doi: 10.1093/brain/awt278. (2013) (IF: 9.915 )


Wieland, A., Trageser, D., Gogolok, S., Reinartz, R., Höfer, H., Keller, M., Leinhaas, A., Eisenreich, R., Normann, S., Klaas, L., Waha, A., Koch, P., Fimmer, R., Pincus., D., Steindler, DA., Brüstle., O., Simon, M., Glas, M., Scheffler, B.

Pleiotropic anticancer effects of niclosamide in human glioblastoma

Clinical Cancer Research 19(15):4124-4136 (IF: 7,742)


Stappert, L., Borghese, L., Roese-Koerner, B., Weinhold, S., Koch, P., Terstegge, S., Uhrberg, M., Wernet, P., Brüstle, O.

MicroRNA-based promotion of human neuronal differentiation and subtype specification

PLoS one 8(3):e59011 (2013) (IF: 4.411)


Glas, M., Coch, C., Trageser, D., Daßler, J., Simon, M., Koch, P., Mertens, J., Quandel, T., Gorris, R., Reinartz, R., Wieland, A., von Lehe, M., Pusch, A., Roy, K., Schlee, M., Neumann, H., Fimmers, R., Herrlinger, U., Brüstle, O., Hartmann, G., Besch, R., Scheffler, B.

Targeting the Cytosolic Immune Receptors RIG-I and MDA5 Effectively Counteracts Cancer Cell Heterogeneity in Glioblastoma.

Stem Cells 31(6):1064-1074 (2013) (IF: 7.871)


McLaren, D., Gorba, T., Marguerie de Rotrou, A., Pillai, G., Chappell, C., Stacey, A., Lingard, S., Falk, A., Smith, A., Koch, P., Brüstle, O., Vickers, R., Tinsley, J., Flanders, D., Bello, P., Craig, S.

Automated large-scale culture and medium-throughput chemical screen for modulators of proliferation and viability of human induced pluripotent stem cell-derived neuroepithelial-like stem cells

J Biomol Screen 18(3):258-68 (2013) (IF: 2.049)


Roese-Koerner, B., Muertz, L., Koch, P., Brüstle, O., Borghese, L.
Pluripotent stem cell-derived somatic stem cells as tool to study the role of microRNAs in early human neural development

Curr Mol Med  13(5):707-722 (2013) (IF: 5.1)



Koch, P., Taboli, I., Mertens, J., Ladewig, J., Stüber, K., Brüstle., O., Walter, J.

Presenilin-1 L166P Mutant Human Pluripotent Stem Cell-Derived Neurons Exhibit Partial Loss of γ-Secretase Activity in Endogenous Amyloid-ß Generation

Am J Pathol. 180(6):2404-2416 (2012) (IF: 5.224)

The American journal of pathology 2012 Koch.pdf (3767735)


Ladewig, J., Mertens, J.*, Kesavan, J.*, Doerr, J., Poppe, D., Glaua, F., Herms, S., Wernet, P., Kögler, G., Müller, F.-J., Koch, P.*, Brüstle, O.* (2012)

Small molecules enable highly efficient neuronal conversion of human fibroblast

(* corresponding authors)

Nature Methods 9(6):575-578 (2012) (IF: 23.565)

Nat Methods 2012 Ladewig.pdf (1092152)


Oki, K.*, Tatarishvili, J*, Wood, J*, Koch,  P*, Mine, Y., Monni, E., Wattanati, S., Brüstle, O., Lindvall, O., Zaal, K.

Human induced pluripotent stem cells form functionally integrated neurons and improve recovery after transplantation in stroke-damaged rodent brain

(*equal contribution)

Stem Cells. Apr 11. doi: 10.1002/stem.1104. (2012) (IF: 7.871)


Falk, A.*, Koch, P.*, Kesavan, J., Takashima, Y., Ladewig, J., Alexander, M., Smith, A., Brüstle, O.

Capture of neuroepithelial-like stem cells from pluripotent stem cellsprovides a versatile system for in vitro production of human neurons

(* equal contribution)

PLoS One 7(1):e29597. (2012) (IF: 4.411)


Steinbeck, JA., Koch, P., Derouiche, A., Brüstle, O.

Human embryonic stem cell-derived neurons establish region-specific, long-range projections in the adult brain.

Cell Mol Life Sci. Feb;69(3):461-70. (2012) (IF: 7.047)


Ahmad, A., Wolber, W., Eckardt, S., Koch, P., Schmitt, J., Semechkin, R., Geis, C., Heckmann, M., Brüstle, O., McLaughlin, J.K., Sirén, A.-L., Müller, A.

Functional neuronal cells generated by human parthenogenetic stem cells.

PLoS One 7(8):e42800 (2012) (IF: 4.411)



Koch, P., Breuer, P., Peitz, M., Jungverdorben, J., Kesavan, J., Poppe, D., Doerr, J., Ladewig, J., Mertens, J., Tüting, T., Hoffmann, P., Klockgether, T., Evert, B.O., Wüllner, U., Brüstle, O.

Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.

Nature. Nov 23;480(7378):543-6. (2011) (IF: 38.597)

Selected by Faculty of 1000

Nature 2011 Koch.pdf (1312698)


Iliou MS, Lujambio A, Portela A, Brüstle O, Koch P, Andersson-Vincent PH, Sundström E, Hovatta O, Esteller M. “Bivalent histone modifications in stem cells poise miRNA loci for CpG island hypermethylation in human cancer” Epigenetics. Nov 1;6(11). (2011) (IF: 4.58)


Milde, T., Kleber, S., Korshunov, A., Witt, H., Hielscher, T., Koch. P., Kopp, H-G., Jugold, M., Deubzer, H., Oehme, I., Lodrini, M., Gröne, HJ., Brenner, A., Brüstle, O., Gilbertson, R., von Deimling, A., Kulozik, AE., Pfister, SM., Martin-Villalba, A., Witt, O. “A novel human high-risk ependymoma stem cell model         reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat.” Acta Neuropathol. Nov;122(5):637-50. (2011) (IF: 7.695)



Terstegge, S., Winter, F., Rath, B.H., Laufenberg, I., Schwarz, C., Leinhaas, A., Levod, F., Dolf, A., Haupt, S., Koch, P., Endl, E., Brüstle, O. (2010) “Laser-assisted photoablation of human pluripotent stem cells from differentiating cultures” Stem Cell Rev. Jun;6(2):260-9. (2010) (IF: 5,08)


Borghese, L., Dolezalova, D., Opitz, T., Haupt, S., Leinhaas, A., Steinfarz, B., Koch, P., Edenhofer, F., Hampl, A., Brüstle, O. (2010) “Inhibition of Notch signaling in human embryonic stem cell–derived neural stem cells delays G1/s phase transition and accelerates neuronal differentiation in vitro and in vivo” Stem Cells. May;28(5):955-64. (2010) (IF: 7.871)




Koch, P., Opitz, T., Steinbeck, J., Ladewig, J., Brüstle, O. “A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration” Proc Natl Acad Sci U S A. Mar 3;106(9):3225-30. (2009) (IF: 9.971)

Proc Natl Acad Sci USA 2009 Koch.pdf (4193523)


Corsini NS, Sancho-Martinez I, Laudenklos S, Glagow D, Kumar S, Letellier E, Koch P., Teodorczyk M, Kleber S, Klussmann S, Wiestler B, Brüstle O, Mueller W, Gieffers C, Hill O, Thiemann M, Seedorf M, Gretz N, Sprengel R, Celikel T, Martin-Villalba A. “The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair. Cell Stem Cell. Aug 7;5(2):178-90. (2009) (IF: 25.943)


Papadimou, E., Moiana, A., Goffredo, D., Koch, P., Bertuzzi, S., Brüstle, O., Cattaneo, E., Conti, L. “p66ShcA adaptor molecule accelerates ES cell neural induction” Mol Cell Neurosci. May;41(1):74-84. (2009) (IF: 3.861)




Ladewig, J*., Koch, P.*., Endl, E., Meiners, B., Opitz, T., Couillard-Despres, S., Aigner, L., Brüstle, O. “Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons” (* equal contribution) Stem Cells. Jul;26(7):1705-12. (2008) (IF: 7.871)

Stem Cells 2008 Ladewig-2.pdf (4363965)


Koch, P., Siemen, H., Biegler, A., Itskovitz-Eldor, J., Brüstle, O. „Transduction of human embryonic stem cells by ecotropic retroviral vectors.“ Nucleic Acids Research 34 (18), e120-e120 (2006) (IF: 8.278)


Li, T., Steinbeck, JA., Lusardi, T., Koch, P., Lan, JQ., Wilz, A., Segeschneider, M., Simon, RP., Brüstle, O., Boison, D “Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain transplants.” Brain. May;130(Pt 5):1276-88. (2007) (IF: 9.915)


Nolden, L., Edenhofer, F., Haupt, S., Koch, P., Wunderlich, T.F., Siemen, H., Brüstle, O. „Genetic engineering of human embryonic stem cells by cell-permeable Cre recombinase“. Nat Methods. Jun;3(6):461-7. (2006) (IF: 23.565)


Simon, M., Bostrom, J., Koch, P., Schramm, J. „Inter-institutional variance of postoperative radiotherapy and follow up for meningiomas in Germany. Impact of changes of the WHO classification.“ J Neurol Neurosurg Psychiatry. Jun;77(6):767-73. (2006) (IF: 4.791)


(before 2006)


Siemen, H., Nix, M., Endl, E., Koch, P., Itskovitz-Eldor, J., Brüstle, O. „Nucleofection of human embryonic stem cells.“ Stem Cells Dev. Aug;14(4):378-83. (2005) (IF: 4.791)


Roth, J., Lenz-Bauer, C., Contente, A., Lohr, K., Koch, P., Bernard, S., Dobbelstein, M. „Reactivation of mutant p53 by a one-hybrid adaptor protein.“ Cancer Res. Jul 15;63(14):3904-8. (2003) (IF: 8.234)


Koch, P., Gatfield, J., Lober, C., Hobom, U., Lenz-Stoppler, C., Roth, J., Dobbelstein, M. „Efficient replication of adenovirus despite the overexpression of active and nondegradable p53.“ Cancer Res. Aug 1;61(15):5941-7. (2001) (IF: 8.234)


Roth, J., Koch, P., Contente, A., Dobbelstein, M. „Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain.“ Oncogene. Mar 30;19(14):1834-42. (2000) (IF: 7.414)


II.) Case Reports


Love, S., Koch, P., Urbach, H., Dawson, TP. „Chronic granulomatous herpes simplex encephalitis in children.“ J Neuropathol Exp Neurol. Nov;63(11):1173-81. (2004) (IF: 4.19)


III.) Reviews

Ladewig, J.*, Koch, P.*, Brüstle, O. “Leveling Waddington: The Emergence of Direct Programming and the Loss of Cell Fate Hierarchies” Nature Reviews Molecular Cell Biology 14(4):225-236 (2013) (*equal contribution) (IF: 39,123)

Nat Rev Mol Cell Biol 2013 Ladewig.pdf (980414)


Koch, P., Kokaia, Z., Lindvall, O., Brüstle, O. “Emerging concepts in neural stem cell research: autologous repair and cell-based disease modeling” Lancet Neurology Sep;8(9):819-29. (2009) (IF: 23.917)

The Lancet Neurology 2009 Koch.pdf (1289125)


IV.) Book Chapters


Mertens, J., Koch, P., Brüstle, O. (2013) Human pluripotent and multipotent stem cells as tools for modeling neurodegeneration In: Programmed Cells from Basic Neuroscience to Therapy (Eds.: Gage, F.H., Christen, Y.), Research and Perspectives in Neurosciences, Foundation IPSEN, Springer, pp.57-66.


Koch, P., Müller, F.-J., Brüstle, O. “Differentiation of human pluripotent stem cells into neural precursors” In: Human stem cell manual - A laboratory guide (eds.: Loring, J.F & Peterson, S.E.), 2nd edition, Elsevier Press, pp. 375-384 (2012)


Siemen, H., Nolden, L., Terstegge, S., Koch, P., Brüstle, O. “Nucleofection of human embryonic stem cells” Methods Mol Biol. 423:131-8. (2008)

The Koch Lab

Dr. Philipp Koch (MD)

Institute of Reconstructive Neurobiology
University of Bonn Medical Campus

Sigmund-Freud-Str. 25
Life&Brain Buld.
53127 Bonn
+49 228 6885 548