Full Publication List

I.) Original Papers



Vadodaria, KC., Mertens, J., Paquola, A., Bardy, C., Li, X., Jappelli, R., Fung, L., Marchetto, MC., Hamm, M., Gorris, M., Koch, P., Gage, FH. ‚Generation of functional human serotonergic neurons from fibroblasts’ Molecular Psychiatry Jan;21(1):49-61. doi: 10.1038/mp.2015.161. (2016) (IF: 14.496)

Ben Halima, S., Mishra, S., Poopathi Raja, M., Willem, M., Baici, A., Simons, K., Brüstle, O., Koch, P., Haass, C., Caflisch, A., Rajendran, L. ‚Specific inhibition of β-secretase processing of the Alzheimer’s disease Amyloid Precursor Protein’ Cell Reports doi: 10.1016/j.celrep.2016.01.076 (2016) (IF: 8.358)

Kumar, S., Wirths, O., Stüber, K., Wunderlich, P., Koch, P., Theil, S., Rezaei-Ghaleh, N., Zweckstetter, M., Bayer, TA., Brüstle, O., Thal, DR., Walter, J. ‚Phosphorylation of the amyloid beta-peptide at Ser26 stabilizes oligomeric assembly and increases neurotoxicity.’ Acta Neuropathologica, 2016 Feb 22 (2016) (IF: 11.360)

Portelius E., Durieu E., Bodin M., Cam M., Pannee J., Leuxe C., Mabondzo A., Oumata N., Galons H., Lee JY., Chang YT., Stϋber K., Koch P., Fontaine G., Potier MC., Manousopoulou A., Garbis S., Covaci A., Van Dam D., De Deyn P., Karg F., Flajolet M., Omori C., Hata S., Suzuki T., Blennow K., Zetterberg H., Meijer L. ‘Specific Triazine Herbicides Induce Amyloid-β42 Production’ J Alzheimers Dis. 2016 Sep 2. (2016) (IF: 4.151)



Doerr, J., Böckenhoff, A., Ewald, B., Ladewig, J., Eckhardt, M., Gieselmann, V., Matzner, U., Brüstle, O. and Koch, P. ‘Arylsulfatase A overexpressing human iPSC-derived neural cells reduce central nervous sulfatide storage in a mouse model of metachromatic leukodystrophy’ Molecular Therapy Sep;23(9):1519-31. doi: 10.1038/mt.2015.106. (2015) (IF: 6.227)



Ladewig, J.*, Koch, P.*, Brüstle, O. ‘Auto-attraction of neural precursors and their neuronal progeny impairs neuronal migration’ Nature Neuroscience 17(1):24-6. doi: 10.1038/nn.3583. Epub 2013 Nov 17. (2014), (* equal contribution) (IF: 16.724)

Avaliani, N., Sørensen, AT., Ledri, M., Bengzon, J., Koch, P., Brüstle, O., Deisseroth, K., Andersson, M., Kokaia, M., ‘Optogenetics reveal delayed afferent synaptogenesis on grafted human induced pluripotent stem cell-derived neural progenitors’ Stem Cells doi: 10.1002/stem.1823. (2014) (IF: 7.781)

Tatarishvili, J., Oki, K., Monni, E., Koch, P., Memanishvili, T., Buga, A.-M., Verma, V., Popa-Wagner, A., Brüstle., O., Lindvall, O., Kokaia, Z ‘Human induced pluripotent stem cells improve recovery in stroke-injured aged rats’ Restorative Neurology and Neuroscience 32(4):547-58. doi: 10.3233/RNN-140404. (2014) (IF: 2.9)



Mertens, J., Stüber, K., Wunderlich, P., Ladewig, J., Vandenberghe, R., Vandenbulcke, M., van Damme, P., Walter, J., Brüstle, O., and Koch, P. ‘APP Processing in Human Pluripotent Stem Cell-Derived Neurons is Resistant to NSAID-based γ-Secretase Modulation’ Stem Cell Reports 1(6):491-8. doi: 10.1016/j.stemcr.2013.10.011. (2013) (IF: 7.023)

Tornero, D., Wattanant, S., Madsen, MG., Koch, P., Wood, J., Tatarishvili, J., Mine, Y., Ge, R., Monni, E., Devaraju, K., Hevner, RF., Brüstle, O., Lindvall, O., Kokaia, Z. ‘Human iPS cell-derived cortical neurons integrate in stroke-injured cortex and impove functional recovery’ Brain 136(Pt 12):3561-77. doi: 10.1093/brain/awt278. (2013) (IF: 10.103)

Mertens, J., Stüber, K., Poppe, D., Doerr, J., Ladewig, J., Brüstle, O., Koch, P. „Embryonic stem cell-based modeling of tau pathology in human neurons’ Am J Pathol 182(5):1769-1779 (2013) (IF: 5.224)

Wieland, A., Trageser, D., Gogolok, S., Reinartz, R., Höfer, H., Keller, M., Leinhaas, A., Eisenreich, R., Normann, S., Klaas, L., Waha, A., Koch, P., Fimmer, R., Pincus., D., Steindler, DA., Brüstle., O., Simon, M., Glas, M., Scheffler, B. ‘Pleiotropic anticancer effects of niclosamide in human glioblastoma’ Clinical Cancer Research 19(15):4124-4136 (2013) (IF: 7.742)

Stappert, L., Borghese, L., Roese-Koerner, B., Weinhold, S., Koch, P., Terstegge, S., Uhrberg, M., Wernet, P., Brüstle, O. „MicroRNA-based promotion of human neuronal differentiation and subtype specification’ PLoS one 8(3):e59011 (2013) (IF: 4.411)

Glas, M., Coch, C., Trageser, D., Daßler, J., Simon, M., Koch, P., Mertens, J., Quandel, T., Gorris, R., Reinartz, R., Wieland, A., von Lehe, M., Pusch, A., Roy, K., Schlee, M., Neumann, H., Fimmers, R., Herrlinger, U., Brüstle, O., Hartmann, G., Besch, R., Scheffler, B. „Targeting the Cytosolic Immune Receptors RIG-I and MDA5 Effectively Counteracts Cancer Cell Heterogeneity in Glioblastoma.’ Stem Cells 31(6):1064-1074 (2013) (IF: 7.871)

McLaren, D., Gorba, T., Marguerie de Rotrou, A., Pillai, G., Chappell, C., Stacey, A., Lingard, S., Falk, A., Smith, A., Koch, P., Brüstle, O., Vickers, R., Tinsley, J., Flanders, D., Bello, P., Craig, S. ‘Automated large-scale culture and medium-throughput chemical screen for modulators of proliferation and viability of human induced pluripotent stem cell-derived neuroepithelial-like stem cells’ J Biomol Screen 18(3):258-68 (2013) (IF: 2.049)

Roese-Koerner, B., Muertz, L., Koch, P., Brüstle, O., Borghese, L. ‘Pluripotent stem cell-derived somatic stem cells as tool to study the role of microRNAs in early human neural development’, Curr Mol Med 13(5):707-722 (2013) (IF: 5.1)



Koch, P., Taboli, I., Mertens, J., Ladewig, J., Stüber, K., Brüstle., O., Walter, J. ‘Presenilin-1 L166P ‘Mutant Human Pluripotent Stem Cell-Derived Neurons Exhibit Partial Loss of γ-Secretase Activity in Endogenous Amyloid-ß Generation’ Am J Pathol. 180(6):2404-2416 (2012) (IF: 5.224)

Ladewig, J., Mertens, J.*, Kesavan, J.*, Doerr, J., Poppe, D., Glaua, F., Herms, S., Wernet, P., Kögler, G., Müller, F.-J., Koch, P.*, Brüstle, O.* (2012) ‘Small molecules enable highly efficient neuronal conversion of human fibroblast’ (* corresponding authors) Nature Methods 9(6):575-578 (2012) (IF: 35.028)

Oki, K.*, Tatarishvili, J*, Wood, J*, Koch,  P*, Mine, Y., Monni, E., Wattanati, S., Brüstle, O., Lindvall, O., Zaal, K. ‘Human induced pluripotent stem cells form functionally integrated neurons and improve recovery after transplantation in stroke-damaged rodent brain’ (*equal contribution) Stem Cells. Apr 11. doi: 10.1002/stem.1104. (2012) (IF: 7.871)

Falk, A.*, Koch, P.*, Kesavan, J., Takashima, Y., Ladewig, J., Alexander, M., Smith, A., Brüstle, O. ‘Capture of neuroepithelial-like stem cells from pluripotent stem cellsprovides a versatile system for in vitro production of human neurons’ (* equal contribution) PLoS One 7(1):e29597. (2012) (IF: 4.411)

Steinbeck, JA., Koch, P., Derouiche, A., Brüstle, O. ‘Human embryonic stem cell-derived neurons establish region-specific, long-range projections in the adult brain.’ Cell Mol Life Sci. Feb;69(3):461-70. (2012) (IF: 7.047)

Ahmad, A., Wolber, W., Eckardt, S., Koch, P., Schmitt, J., Semechkin, R., Geis, C., Heckmann, M., Brüstle, O., McLaughlin, J.K., Sirén, A.-L., Müller, A. ‘Functional neuronal cells generated by human parthenogenetic stem cells.’ PLoS One 7(8):e42800 (2012) (IF: 4.411)



Koch, P., Breuer, P., Peitz, M., Jungverdorben, J., Kesavan, J., Poppe, D., Doerr, J., Ladewig, J., Mertens, J., Tüting, T., Hoffmann, P., Klockgether, T., Evert, B.O., Wüllner, U., Brüstle, O. ‘Excitation-induced ataxin-3 aggregation in neurons from patients with Machado-Joseph disease.’ Nature. Nov 23;480(7378):543-6. (2011) (IF: 42.221)

Iliou MS, Lujambio A, Portela A, Brüstle O, Koch P, Andersson-Vincent PH, Sundström E, Hovatta O, Esteller M. ‘Bivalent histone modifications in stem cells poise miRNA loci for CpG island hypermethylation in human cancer’ Epigenetics. Nov 1;6(11). (2011) (IF: 4.58)

Milde, T., Kleber, S., Korshunov, A., Witt, H., Hielscher, T., Koch. P., Kopp, H-G., Jugold, M., Deubzer, H., Oehme, I., Lodrini, M., Gröne, HJ., Brenner, A., Brüstle, O., Gilbertson, R., von Deimling, A., Kulozik, AE., Pfister, SM., Martin-Villalba, A., Witt, O. ‘A novel human high-risk ependymoma stem cell model reveals the differentiation-inducing potential of the histone deacetylase inhibitor Vorinostat.’ Acta Neuropathol. Nov;122(5):637-50. (2011) (IF: 11.360)



Terstegge, S., Winter, F., Rath, B.H., Laufenberg, I., Schwarz, C., Leinhaas, A., Levod, F., Dolf, A., Haupt, S., Koch, P., Endl, E., Brüstle, O. (2010) ‘Laser-assisted photoablation of human pluripotent stem cells from differentiating cultures’ Stem Cell Rev. Jun;6(2):260-9. (2010) (IF: 5.08)

Borghese, L., Dolezalova, D., Opitz, T., Haupt, S., Leinhaas, A., Steinfarz, B., Koch, P., Edenhofer, F., Hampl, A., Brüstle, O. (2010) ‘Inhibition of Notch signaling in human embryonic stem cell–derived neural stem cells delays G1/s phase transition and accelerates neuronal differentiation in vitro and in vivo’ Stem Cells. May;28(5):955-64. (2010) (IF: 7.871)



Koch, P., Opitz, T., Steinbeck, J., Ladewig, J., Brüstle, O. ‘A rosette-type, self-renewing human ES cell-derived neural stem cell with potential for in vitro instruction and synaptic integration’ Proc Natl Acad Sci U S A. Mar 3;106(9):3225-30. (2009) (IF: 9.971)

Corsini NS, Sancho-Martinez I, Laudenklos S, Glagow D, Kumar S, Letellier E, Koch P., Teodorczyk M, Kleber S, Klussmann S, Wiestler B, Brüstle O, Mueller W, Gieffers C, Hill O, Thiemann M, Seedorf M, Gretz N, Sprengel R, Celikel T, Martin-Villalba A. ‘The death receptor CD95 activates adult neural stem cells for working memory formation and brain repair. Cell Stem Cell. Aug 7;5(2):178-90. (2009) (IF: 25.943)

Papadimou, E., Moiana, A., Goffredo, D., Koch, P., Bertuzzi, S., Brüstle, O., Cattaneo, E., Conti, L. ‘p66ShcA adaptor molecule accelerates ES cell neural induction’ Mol Cell Neurosci. May;41(1):74-84. (2009) (IF: 3.861)



Ladewig, J*., Koch, P.*., Endl, E., Meiners, B., Opitz, T., Couillard-Despres, S., Aigner, L., Brüstle, O. ‘Lineage selection of functional and cryopreservable human embryonic stem cell-derived neurons’ (* equal contribution) Stem Cells. Jul;26(7):1705-12. (2008) (IF: 7.871)

Siemen, H., Nolden, L., Terstegge, S., Koch, P., Brüstle, O. ‘Nucleofection of human embryonic stem cells’ Methods Mol Biol. 423:131-8. (2008) (IF: 13.900)

Li, T., Steinbeck, JA., Lusardi, T., Koch, P., Lan, JQ., Wilz, A., Segeschneider, M., Simon, RP., Brüstle, O., Boison, D ‘Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain transplants.’ Brain. May;130(Pt 5):1276-88. (2007) (IF: 10.103)

Koch, P., Siemen, H., Biegler, A., Itskovitz-Eldor, J., Brüstle, O. „Transduction of human embryonic stem cells by ecotropic retroviral vectors.’ Nucleic Acids Research 34 (18), e120-e120 (2006) (IF: 8.278)

Nolden, L., Edenhofer, F., Haupt, S., Koch, P., Wunderlich, T.F., Siemen, H., Brüstle, O. „Genetic engineering of human embryonic stem cells by cell-permeable Cre recombinase’. Nat Methods. Jun;3(6):461-7. (2006) (IF: 35.028)

Simon, M., Bostrom, J., Koch, P., Schramm, J. „Inter-institutional variance of postoperative radiotherapy and follow up for meningiomas in Germany. Impact of changes of the WHO classification.’ J Neurol Neurosurg Psychiatry. Jun;77(6):767-73. (2006) (IF: 4.791)


(before 2006)

Siemen, H., Nix, M., Endl, E., Koch, P., Itskovitz-Eldor, J., Brüstle, O. „Nucleofection of human embryonic stem cells.’ Stem Cells Dev. Aug;14(4):378-83. (2005) (IF: 4.791)

Roth, J., Lenz-Bauer, C., Contente, A., Lohr, K., Koch, P., Bernard, S., Dobbelstein, M. „Reactivation of mutant p53 by a one-hybrid adaptor protein.’ Cancer Res. Jul 15;63(14):3904-8. (2003) (IF: 8.234)

Koch, P., Gatfield, J., Lober, C., Hobom, U., Lenz-Stoppler, C., Roth, J., Dobbelstein, M. „Efficient replication of adenovirus despite the overexpression of active and nondegradable p53.’ Cancer Res. Aug 1;61(15):5941-7. (2001) (IF: 8.234)

Roth, J., Koch, P., Contente, A., Dobbelstein, M. „Tumor-derived mutations within the DNA-binding domain of p53 that phenotypically resemble the deletion of the proline-rich domain.’ Oncogene. Mar 30;19(14):1834-42. (2000) (IF: 7.414)


II.) Case Reports

Love, S., Koch, P., Urbach, H., Dawson, TP. „Chronic granulomatous herpes simplex encephalitis in children.’ J Neuropathol Exp Neurol. Nov;63(11):1173-81. (2004) (IF: 4.19)


III.) Reviews/ Book Chapters

Koch, P. ‘Direct Coversion Provides Old Neurons from Aged Donor’s Skin’ Cell Stem Cell Dec 3;163(6):1527-38. doi: 10.1016/j.cell.2015.10.071. (2015) (IF: 22.268)

Ladewig, J.*, Koch, P.*, Brüstle, O. ‘Leveling Waddington: The Emergence of Direct Programming and the Loss of Cell Fate Hierarchies’ Nature Reviews Molecular Cell Biology 14(4):225-236 (2013) (*equal contribution) (IF: 39.123)

Koch, P., Kokaia, Z., Lindvall, O., Brüstle, O. ‘Emerging concepts in neural stem cell research: autologous repair and cell-based disease modeling’ Lancet Neurology Sep;8(9):819-29. (2009) (IF: 23.917)

Mertens, J., Koch, P., Brüstle, O. (2013) Human pluripotent and multipotent stem cells as tools for modeling neurodegeneration In: Programmed Cells from Basic Neuroscience to Therapy (Eds.: Gage, F.H., Christen, Y.), Research and Perspectives in Neurosciences, Foundation IPSEN, Springer, pp.57-66.

Koch, P., Müller, F.-J., Brüstle, O. ‘Differentiation of human pluripotent stem cells into neural precursors’ In: Human stem cell manual - A laboratory guide (eds.: Loring, J.F & Peterson, S.E.), 2nd edition, Elsevier Press, pp. 375-384 (2012)


IV.) Patents

Ladewig, J., Koch, P., Brüstle, O. (2009) Promotion of neuronal integration in neural stem cell grafts. PCT/EP2009/002149; PCT/EP2010/001841

The Koch Lab

Dr. Philipp Koch (MD)

Institute of Reconstructive Neurobiology
University of Bonn Medical Campus

Sigmund-Freud-Str. 25
Life&Brain Buld.
53127 Bonn
+49 228 6885 548 philipp.koch@uni-bonn.de